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PROGRESS
REPORT

THE GRIFOLS
CHAIR
STUDIES

INTRODUCTION

The main objective of the Grifols Chair for Translational Research is to foster and promote research studies aimed at characterizing the mechanisms underlying the presence of systemic inflammation in patients with decompensated cirrhosis and its role in the development of ACLF. In particular, the Grifols Chair is paying special attention to the mechanisms responsible for the therapeutic properties of albumin infusions in the prevention of organ failure(s) in these patients.

The EF Clif designed a full proposal of research activities for the 2018 period, which were focused on the therapeutic actions of albumin in vitro and the investigation of samples collected during clinical studies in which albumin infusion was employed as the main therapy. In broad terms, the 2018 proposal had three specific objectives:

  • 1To establish new biology associated with the anti-inflammatory properties of albumin.
  • 2To apply cutting-edge technology to understand the biological properties of albumin.
  • 3To provide proof-of-concept of the “anti-inflammatory properties” of albumin in clinical studies.
MAIN RESULT

> THE IMMUNOMODULATION EFFECTS OF ALBUMIN

PI: Joan Clària (Hospital Clínic, Barcelona, Spain).
Promoter: EF Clif